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Rodent Models with Humanized Liver: A Tool to Study Human Pathogens

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Published by INTECH Open Access Publisher .
Written in English

Book details:

Edition Notes


ContributionsDina Kremsdorf, author, Nicolas Brezillon, author
The Physical Object
Pagination1 online resource
ID Numbers
Open LibraryOL27071503M
ISBN 109535106228
ISBN 109789535106227

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These humanized mice provide a powerful tool to study the physiopathology of human hepatotropic pathogens and to develop drugs against them. Finally, emphasis will be placed on the role of these rodent models in the demonstration of the hepatocytic potential of stem by: 9. The present study examined the in vivo induction potency of human CYP3A in chimeric mice with humanized liver, recently established in Japan, by a specific inducer of human CYP3A enzyme activity. Dina Kremsdorf. Inserm France. 1 chapters authored. Chapters authored. Rodent Models with Humanized Liver: A Tool to Study Human Pathogens. By Ivan Quétier, Nicolas Brezillon and Dina Kremsdorf. Part of the book: Liver Regeneration. Related .   Humanized mice offer a model unique to all other means of study, providing an in vivo platform for the careful examination of human tropic viruses and their interaction with human cells and tissues. These types of animal models have provided a reliable medium for the study of human-virus interactions, a relationship that could otherwise not be Author: Fatemeh Vahedi, Elizabeth C. Giles, Ali A. Ashkar.

As currently used animal models only partially represent the characteristics of human diseases, it is important to select an animal model that is suitable for the objective of the study. In this chapter, we present a systematic review of currently used animal models of various liver diseases, along with their advantages and by: 1. In comparison to rodent models such as rats (Rattus rattus), mice (Mus musculus), and prairie voles (Microtus ochrogaster), all primate models display a more extended, human-like period of development [Walters, ]. In many species, offspring often remain in the natal group well past the age of Cited by: • new animal models (e.g., humanized liver mouse models) growth of common foodborne pathogens. The study is currently available online at Labeling Review Tool Hundreds of new or updated.   Although valuable information on viral hepatitis emerged from careful epidemiological studies on sporadic outbreaks in humans, experimental Cited by:

  Systematic reviews and standardization of animal model protocols. Because nonhuman animal models (hereafter referred to as animal models or animals) have on multiple occasions been unsuccessful in predicting human response to drugs and disease (we will address this claim in depth), many have called for SRs in order to improve the models An example of this predicament would Cited by: A similar phenomenon has been observed in mouse models of malaria, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. In this study two proteins, SBP1 and MAHRP1, are identified that are conserved between rodent and human malaria parasites and that play a role in. Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities. Despite the improvement in understanding the biology of AML, survival rates remain quite low. Animal models offer a valuable tool to recapitulate different AML subtypes, and to assess the Author: Hala Skayneh, Batoul Jishi, Rita Hleihel, Maguy Hamieh, Nadine Darwiche, Ali Bazarbachi, Marwan El S.   There are fundamental differences between humans and the animals we typically use to study the immune system. We have learned much from genetically manipulated and inbred animal models, but instances in which these findings have been successfully translated to human immunity have been rare. Embracing the genetic and environmental diversity of humans can tell us about the Cited by: 9.